Epioxa: Epithelium-On Cross-Linking

Epioxa: Epithelium-On Cross-Linking

Protect your vision at South Florida’s only provider of Epioxa™—the first and only non-invasive, incision-free treatment approved by the FDA to halt the progression of Keratoconus.

The Future of Keratoconus Care is Here

For years, the gold standard for stopping Keratoconus was “epithelium-off” cross-linking—a procedure that required surgically removing the front layer of the cornea. While effective, it meant a painful recovery and a higher risk of complications.

Today, Carrie A. Palmer, M.D. is proud to bring a revolutionary advancement to the Treasure Coast. As the first provider in South Florida to offer the Epioxa™ (Epi-On iLink™), we can now strengthen your cornea and stabilize your vision without a single incision or surgical scrape.

The Future of Keratoconus Care is Here

Epioxa is the next generation of corneal collagen cross-linking (CXL). It is designed to stiffen and strengthen a cornea weakened by Keratoconus, preventing the eye from bulging into a cone shape that causes vision loss.

How the Technology Works

  • Proprietary Riboflavin: We apply a specialized Vitamin B2 formula (Epioxa) that is uniquely engineered to soak through the corneal surface without needing to remove the protective outer layer (the epithelium).
  • The Boost Goggles: To maximize the effect, patients wear specialized goggles that deliver supplemental oxygen to the eye’s surface.
  • UV-A Activation: A precise UV-A light is applied to the eye. The interaction between the oxygen, riboflavin, and light creates new “cross-links” between corneal collagen fibers, acting like invisible biological staples to reinforce the eye.
Close up of eye

Epi-On vs. Traditional Cross-Linking

For years, the gold standard for stopping Keratoconus was “epithelium-off” cross-linking—a procedure that required surgically removing the front layer of the cornea. While effective, it meant a painful recovery and a higher risk of complications.

Today, Carrie A. Palmer, M.D. is proud to bring a revolutionary advancement to the Treasure Coast. As the only provider in South Florida currently offering the Epioxa™ (Epi-On iLink™), we can now strengthen your cornea and stabilize your vision without a single incision or surgical scrape.

Feature Traditional (Epi-Off) Epioxa (Epi-On)
Surgical Incision Yes (scraping of cornea) No (incision-free)
Pain Level Significant (3-5 days) Minimal to None
Recovery Time 1-2 Weeks 24-48 hours
Infection Risk Higher (due to open wound) Significantly lower
South Florida Availability Multiple Providers Dr. Palmer

Who Is a Candidate for Epioxa?

This treatment is specifically FDA-approved for patients with progressive Keratoconus. Because Dr. Palmer is a board-certified ophthalmologist with deep expertise in corneal disorders, she can determine if your condition is at the right stage for this technology.

Reasons You May Benefit From Epioxa

  • You have been diagnosed with Keratoconus or corneal ectasia.
  • Your vision is becoming increasingly blurred or distorted.
  • You want to avoid the pain and downtime of traditional “epi-off” surgery.
  • You are looking to stabilize your vision to prevent the future need for a corneal transplant.
two people running together

Experience South Florida’s Leading Eye Care

When it comes to your sight, experience matters. Dr. Carrie Palmer is at the forefront of ophthalmic technology, ensuring that patients in Stuart, Port St. Lucie, and across South Florida have access to the most advanced medical treatments available. 

By choosing Treasure Coast Eye Specialists, you are choosing a practice that prioritizes patient comfort and long-term visual outcomes.

Hear From Our Patients

Save Your Sight with the Region’s Only Epi-On Specialist

Ready for Clearer Vision? Start Today.

Don’t wait for Keratoconus to progress. Schedule your consultation with Dr. Carrie Palmer today and see if the breakthrough Epioxa treatment is right for you.

Treasure Coast Eye Specialists Eye Exam

Frequently Asked Questions

Yes. Epioxa is the first and only “epi-on” corneal cross-linking therapy to receive FDA approval, providing a safe and proven alternative to traditional methods.

Because the epithelium (the front of the eye) remains intact, there is very little discomfort. Most patients describe a sensation of “grittiness” for a few hours, but nothing compared to the intense pain associated with traditional scraping methods.

The entire process is performed in our office and typically takes about an hour. You will be able to go home immediately following the treatment.

One of the biggest advantages of Epioxa is the rapid recovery. Most patients return to their normal daily activities and work within 24 to 48 hours.

The primary goal of cross-linking is to stabilize the eye and stop the disease from getting worse. While some patients notice a slight improvement in clarity, the procedure is designed to protect your current vision and prevent the need for more invasive surgeries like corneal transplants in the future.